GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2239557 | 1 | rs2358633 | chr14:74647418 | LIN52 | chr14:74551656-74667117:+ | -0.35 | -8.2 | 3.8E-15 | Common traits (Other) |
| BLCA | cis | rs454422 | 1 | rs236104 | chr20:5958960 | MCM8 | chr20:5931298-5975829:+ | -0.21 | -4.54 | 7.7E-6 | HIV-1 viral setpoint |
| BLCA | cis | rs454422 | 1 | rs236121 | chr20:5972594 | MCM8 | chr20:5931298-5975829:+ | -0.21 | -4.36 | 1.67E-5 | HIV-1 viral setpoint |
| BLCA | cis | rs9876781 | 1 | rs2362450 | chr3:48461313 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.92 | 0.000105 | Longevity |
| BLCA | cis | rs6951245 | 1 | rs2363286 | chr7:1091625 | ZFAND2A | chr7:1192544-1199855:- | -0.34 | -4.09 | 5.18E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs7589728 | 1 | rs2363731 | chr2:88521793 | THNSL2 | chr2:88469835-88486145:+ | -0.58 | -5.91 | 7.68E-9 | Plasma clusterin levels |
| BLCA | cis | rs11622475 | 1 | rs2368984 | chr14:104372055 | TDRD9 | chr14:104394817-104519002:+ | 0.34 | 5.59 | 4.26E-8 | Bipolar disorder |
| BLCA | cis | rs7112513 | 1 | rs236918 | chr11:117091609 | PCSK7 | chr11:117075789-117102811:- | 0.37 | 4.63 | 4.91E-6 | Protein quantitative trait loci |
| BLCA | cis | rs10935120 | 1 | rs2370578 | chr3:134199612 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.23 | 2.91E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs2370578 | chr3:134199612 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.44 | 1.16E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs2370641 | chr3:134222161 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.8 | 6.04E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs2370641 | chr3:134222161 | CEP63 | chr3:134204575-134293852:+ | 0.24 | 4.09 | 5.17E-5 | Height |
| BLCA | cis | rs10935120 | 1 | rs2370642 | chr3:134222136 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.18 | 4.34E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs2370642 | chr3:134222136 | CEP63 | chr3:134204575-134293852:+ | 0.26 | 4.46 | 1.07E-5 | Height |
| BLCA | cis | rs11976180 | 1 | rs2371244 | chr7:143757611 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.97 | 5.56E-9 | Obesity-related traits |